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Main Focus
My laboratory investigates the mechanisms of urothelial carcinoma development and the exploration of potential therapeutic strategies. We aim to apply the acquired knowledge to the prevention, diagnosis, and treatment of human diseases and cancers in the future.

Research Projects
The main projects are
1. We focus on the transcription factor CCAAT/enhancer binding protein delta (CEBPD) to study its regulatory role in various signaling pathways in cancer cells under different environmental factors and endogenous stress, aiming to understand the role and mechanisms of CEBPD in cancer development.
2. We explore the molecular mechanisms behind urothelial carcinoma development and the evolved chemoresistance.
3. We work on developing drugs to overcome chemoresistance in cancer cells and investigate the underlying mechanisms.

Grants
1. The role of C/EBPdelta in the maintenance of genomic integrity (2006/1~2006/7)
Grant ID¡GKMU-Q095018 (MKU)
Role¡GPrinciple investigator
2. Molecular mechanisms of C/EBPdelta in apoptosis of breast tumor cells (2006/8~2007/7)
Grant ID¡GNSC 95-2320-B-037-048 (NSC)
Role¡GPrinciple investigator
3. The role of C/EBPdelta in cisplatin resistance (2006/12~2007/7)
Grant ID¡GKMU-Q096009 (KMU)
Role¡GPrinciple investigator
4. Molecular mechanisms of transcription factor Cebpd in maintenance of genome integrity in mouse embryonic fibroblasts (2008/4/1~2008/12/31)
Grant ID¡GKMU-M097004 (KMU)
Role¡GPrinciple investigator
5. Identification of differential expression regulatory networks associated with drug response in chemosensitive and chemoresistant breast cancer(2009/8/1~2010/7/31)
Grant ID¡GNSC 98-2218-E-231-002- (NSC)
Role¡GCo-Principle investigator
6. Molecular mechanisms of CEBPD-mediated cisplatin resistance in human urothelial carcinoma cells (2008/8~2011/7)
Grant ID¡GNSC 97-2320-B-037-018-MY3 (NSC)
Role¡GPrinciple investigator
7. Evaluating CEBPD-mediated pathways in human urothelial carcinoma treatment: the molecular mechanisms in drug resistance (2011/8~2012/7)
Grant ID¡GNSC 100-2320-B-037-013- (NSC)
Role¡GPrinciple investigator
8. Identification of dysregulated pathways using stretched metastasis-induced graph ¡V A case study of prostate cancer (2012/8/1~2013/7/31)
Grant ID¡GNSC 101-2221-E-231-030- (NSC)
Role¡GCo-Principle investigator
9.CEBPD in the tumorigenesis of human urothelial carcinoma (2012/12/1~2013/12/31)
Grant ID¡GKMU-M102008 (KMU)
Role¡GPrinciple investigator
10 . PTEN in CEBPD-mediated cisplatin responsiveness and its applications (2013/8/1~2014/7/31)
Grant ID¡GNSC 102-2320-B-037-026- (NSC)
Role¡GPrinciple investigator
11. CEBPD-mediated chemotherapeutic drug responsiveness and resistance in urothelial carcinoma: focusing on cisplatin-AKT-CEBPD-PTEN axis (2014/8~2015/7)
Grant ID¡G103-2320-B-037 -029 - (Ministry of Science and Technology)
Role¡GPrinciple investigator
12. Applications of cyclooxygenase inhibitors in urothelial carcinoma and cisplatin resistant sublines and the mechanistic studies (2016/1/1~2016/12/31)
Grant ID¡GKMU-M105002 (KMU)
Role¡GPrinciple investigator
13. Long - term surveillance and investigation of Aedes mosquitoes in Kaohsiung City - Southern Kaohsiung Districts (2017/5/1~2017/12/31)
Grant ID¡G NHRI-106A1-MRCO-1017174
Role¡GPrinciple investigator
14.Refining and continuing long-term surveillance and investigation of Aedes mosquitoes in Southern Kaohsiung Districts (2018/1/1~2018/12/31)
Grant ID¡G NHRI-07A1-MRPP33-035
Role¡GPrinciple investigator
15. CEBPD and its miRNA targets in urothelial carcinoma progression and drug resistance development (2018/8/1~2019/07/31)
Grant ID¡GMOST 107-2314-B-037-014 - (Ministry of Science and Technology)
Role¡GPrinciple investigator
16. Establish and optimize the molecular analyzing method for detecting the dengue virus in Aedes mosquitoes (2019/1/1~2019/12/31)
Grant ID¡G NHRI-MR-108-CO-10
Role¡GPrinciple investigator
17.Molecular mechanism of CEBPD regulating microRNA miR-17-92 cluster in upper tract /urothelial carcinoma progression and drug resistance development (2019/08/1~2022/07/31)
Grant ID¡GMOST 108-2314-B-037-031-MY3 (Ministry of Science and Technology)
Role¡GPrinciple investigator
18. Exploration of the deubiquitinase USP2a targets in urothelial carcinoma tumorigenesis and chemotherapeutic drug responses (2023/1/1~2023/12/31)
Grant ID¡GKMU-M112020 (KMU)
Role¡GPrinciple investigator

Posters (click)

Patents
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ÃҮѸ¹½X: I386415 (¤¤µØ¥Á°ê)
2.±M§Q¦WºÙ: §@¥Î©ó·L¤pºÞ§ÜÀùÃĪ«2',5'-dimethoxychalcone­l¥Íª«¤§¦X¦¨»P¬¡©Êµû¦ô
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±M§QÃҮѸ¹½X: I419687 (¤¤µØ¥Á°ê)
3.±M§Q¦WºÙ: §Ü¤HÃþªc§¿¤W¥ÖÀù¤§­»®Û¶WÁ{¬ÉµÑ¨úª«¡B»s³Æ¤èªk¤Î¥Î³~
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±M§QÃҮѸ¹½X: I448295 (¤¤µØ¥Á°ê)
4.±M§Q¦WºÙ:The anti-human urothelial carcinoma of supercritical carbon dioxide extract of cinnamomum subavenium, and the preparation process and uses
µo©ú¤H: §õ§ÓùÚ¡B¶Àªü±ö¡B³¯¤¤¤@¡B³s°öºa¡B¼Bã´f
(Jih-Heng Li, A-Mei Huang, Chung-Yi Chen, Pei-Jung Lien, Chiung-Hui Liu)
±M§QÃҮѸ¹½X:US8,669,377B2 (¬ü°ê)
5. ±M§Q¦WºÙ: ºµªG»Ä­l¥Íª«¤Î¨äÂåÅ@²Õ¦Xª«
µo©ú¤H: ªL©¾¨k¡BÒ\¬Ó³ó¡B¶Àªü±ö¡BÃQ¦Ê¸S¡BÃCª÷»ñ¡B«J¦Û»Í¡B·¨¥@¸s¡B»Z¥Ã§µ¡B¯Î²ì»x
ÃҮѸ¹½X: US 8729055B2 (¬ü°ê)
6.±M§Q¦WºÙ: 18£]-¥Ì¯ó¦¸»Ä­l¥Íª«¤Î¨ä¥Î³~
µo©ú¤H: ªL©¾¨k¡BªL³Í°¶¡B¶Àªü±ö¡B«J¦Û»Í¡B·¨¥@¸s¡B»Z¥Ã§µ¡B±i«Ø°ê
ÃҮѸ¹½X: I424839 (¤¤µØ¥Á°ê)
7.±M§Q¦WºÙ: Derivative of 18£]-glycyrrhetinic acid APT to suppress cancer cells
µo©ú¤H: ªL©¾¨k¡BªL³Í°¶¡B¶Àªü±ö¡B«J¦Û»Í¡B·¨¥@¸s¡B»Z¥Ã§µ¡B±i«Ø°ê
ÃҮѸ¹½X: US 8,686,178 B2 (¬ü°ê)

Publications

No.	Title	Journal	IF and ranking
1	Huang, AM, Chang, TJ, Cho, WL, and Chou, CK. 1998. From mosquito to man: identification of a novel protein kinase, HsHPK, which is highly expressed in human hepatoma tissues.(pdf)	J. Biomed. Sci. 1998. 5(2): 135-140. (SCI)	IF: 2.013 ranking: 45/82 (2008)
2	Lee, HS, Huang, AM, Huang, GT, Yang, PM, Chen, PJ, Sheu, JC, Lai, MY, Lee, SC, Chou, CK, and Chen, DS. 1998. Hepatocyte growth factor stimulates the growth and activates mitogen-activated protein kinase in human hepatoma cells. (pdf)	J. Biomed. Sci. 1998. 5(3): 180-184. (SCI)	IF: 2.013 ranking: 45/82 (2008)
3	Shen, HH, Huang, AM, Hoheisel, J, and Tsai, SF. 2001. Identification and characterization of a SET/NAP protein encoded by a brain-specific gene, MB20. (pdf)	Genomics. 2001. 71(1): 21-33. (SCI)	IF: 3.327 ranking: 37/152 (2009)
4	Liu, MA, Huang, AM, Chou, CK, Liaw, GJ, and Wu, CW. 2001. Utilization of Drosophila eye to probe the functions of two mammalian Serine/Threonine kinases, Snk and HsHPK. (pdf)	J. Biomed. Sci. 2001. 8(3): 270-277. (SCI)	IF: 2.013 ranking: 45/82 (2008)
5	Huang, AM, Montagna, C, Ni, Y, Sharan, S, Ried, T and Sterneck, E. 2004. Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability. (pdf)	Oncogene. 2004. 23(8): 1549-1557. (SCI)	IF:7.216 ranking: 13/141
6	Thangaraju M, Rudelius, M, Bierie, B, Raffeld, M, Sharan, S, Hennighausen, L, Huang, AM, and Sterneck, E. 2005. C/EBP delta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution. (pdf)	Development. 2005. 132(21):4675-4685. (SCI)	IF: 6.812 ranking: 5/37
7	Huang, AM, Rudelius, M, Sharan, S, McAllister, JM, Raffeld, M, Christenson, LK, and Sterneck, E. 2007. The Cebpd (C/EBPdelta) gene is induced by luteinizing hormones in ovarian theca and interstitial cells but is not essential for mouse ovary function. (pdf)	PLoS ONE 2007. 2: e1334. (SCI)	IF: 4.351 ranking: 9/73 (2009)
8	Lin, KW#, Huang, AM#, Tu, HY, Weng, JR, Hour, TC, Wei, BL, Yang, SC, Wang, JP, Pu, YS, and Lin, CN*. 2009. Phloroglucinols inhibit chemical mediators and xanthine oxidase, and protect cisplatin-induced cell death by reducing reactive oxygen species in normal human urothelial and bladder cancer cells. (pdf)	J Agric Food Chem 2009. 57: 8782-8787. (SCI) (#co-first author)	IF: 2.562 ranking: 2/35 (2008)
9	Tu, HY#, Huang, AM#, Wei, BL, Gan, KH, Hour, TC, Yang, SC, Pu, YS, and Lin, CN*. 2009. Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. (pdf)	Bioorg Med Chem 2009. 17: 7265-7274. (SCI) (#Co-first author)	IF: 3.075 ranking: 10/40 (2008)
10	Pu, YS, Huang, CY, Kuo, YZ, Kang, WY, Liu, GY, Huang, AM, Yu, HJ, Lai, MK, Huang, SP, Wu, WJ, Chiou, SJ, and Hour, TC*. 2009. Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma. (pdf)	J. Biomed. Sci. 2009. 16(1): 82-92. (SCI)	IF: 2.013 ranking: 45/82 (2008)
11	Wang, YC, Tsai, YS, Huang, JL, Lee, KW, Kuo, CC, Wang, CS, Huang, AM, Chang, JG, Jong, YJ and Lin, CS*. 2010. Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and activating spindle assembly checkpoint. (pdf)	Oral Oncology. 2010. 46(4):255-62. (SCI)	IF: 2.928 ranking: 5/55 (2009)
12	Chen, HL, Lin, KW, Huang, AM, Tu, HY, Wei, BL, Hour, TC, Yen, MH, Pu, Y and Lin, CN*. 2010. Terpenoids induce cell cycle arrest and apoptosis from the stems of Celastrus kusanoi associated with reactive oxygen species. (pdf)	J Agric Food Chem 2010. 58(6):3808-12. (SCI)	IF: 2.469 ranking: 2/44 (2009)
13	Tu HY, Huang AM, Hour TC, Yang SC, Pu YS, and Lin CN*. 2010. Synthesis and biological evaluation of 2',5'-dimethoxychalcone derivatives as microtubule-targeted anticancer agents. (pdf)	Bioorg Med Chem. 2010. 18 (6): 2089-2098. (SCI)	IF: 2.822 ranking: 17/57 (2009)
14	Hour, TC, Lai, YL, Kuan, CI, Chou, CK, Wang, JM, Tu, HY, Hu, HT, Lin, CS, Wu, WJ, Pu, YS, Sterneck, E, and Huang, AM*. 2010. Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. (pdf)	Biochem. Pharmacol. 2010. 80(3):325-334. (SCI) (*corresponding author)	IF: 4.254 ranking: 34/237 (2009)
15	Pawar, SA, Sarkar, TR, Balamurugan, K, Sharan, S, Wang, J, Zhang, Y, Dowdy, SY, Huang, AM, and Sterneck E*. 2010. C/EBPdelta targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. (pdf)	Proc Natl Acad Sci USA. 2010. 107(20):9210-5. (SCI)	IF: 9.432 ranking: 3/50 (2009)
16	Huang, CY, Chen, JYF, Wu,JE, Pu, YS, Liu, GY, Pan, MH, Huang, YT, Huang, AM, Hwang, CC, Chung, SJ, and Hour, TC*. 2010. Ling-Zhi polysaccharides potentiates cytotoxic effects of anti-cancer drugs against drug-resistant urothelial carcinoma cell.(pdf)	J Agric Food Chem. 2010. 58(15):8798-805. (SCI)	IF: 2.469 ranking: 2/44 (2009)
17	Wang J, Sarkar TR, Zhou M, Sharan S, Ritt DA, Veenstra TD, Morrison DK, Huang, AM, and Sterneck E*. 2010. C/EBPdelta-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. (pdf)	Proc Natl Acad Sci USA. 2010. 107(37): 16131-6. (SCI)	IF: 9.432 ranking: 3/50 (2009)
18	Lin CN#, Huang AM#, Lin KW#, Hour TC, Ko HH*, Yang SC, and Pu YS. 2010. Xanthine oxidase inhibitory terpenoids of Amentotaxus formosana protect cisplatin-induced cell death by reducing reactive oxygen species (ROS) in normal human urothelial and bladder cancer cells. (pdf)	Phytochemistry 2010. 71(17-18):2140-6. (SCI) (#Co-first author)	IF: 3.104 ranking: 24/173 (2009)
19	Pan YC, Li CF, Ko CY, Pan MH, Chen PJ, Tseng JT, Wu WC, Chang WC, Huang AM, Sterneck E, and Wang JM*. 2010. CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells. (pdf)	Clin Cancer Res. 2010. 16(23):5770-80. (SCI)	IF: 6.747 ranking: 16/166 (2009)
20	Lin, KW#, Huang, AM#, Tu, HY, Lee, LY, Wu, Hour, TC, Yang, SC, Pu, YS and Lin, CN*. 2011. Xanthine Oxidase Inhibitory Triterpenoid and Phloroglucinol from Guttiferaceous Plants Inhibit Growth and Induced Apoptosis in Human NTUB1 Cells Through a ROS-Dependent Mechanism. (pdf)	J Agric Food Chem. 2011. 59(1):407-14. (SCI) (#Co-first author)	IF: 2.816 ranking: 2/55 (2010)
21	Ko, CY, Chang, LH, Lee, YC, Sterneck, E, Cheng, CP, Chen, SH, Huang, AM, Tseng, JT, and Wang, JM*. 2010. CAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. (pdf)	Neurobiology of Aging. 2012. 33(2): 422.e11-422.e25 (SCI)	IF: 6.634 ranking: 3/45 (2010)
22	Cheng,JH#, Huang, AM#, Hour, TC, Yang, SC*, Pu, YS and Lin, CN*. 2011. Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS. (pdf)	Eur J Med Chem. 2011. 46(4):1222-31. (SCI) (#Co-first author)	IF:3.193 ranking: 11/54 (2010)
23	Chao, SY, Chiang, JH*, Huang, AM*, and Chang, WS. 2011. An integrative approach to identifying cancer chemoresistance-associated pathways. (pdf)	BMC Med Genomics 2011. 4(1):23-37. (SCI) (*co-correspondence)	IF:3.766 ranking: 47/156 (2010)
24	Huang, AM*, Kao, YT, Toh, S, Lin, PY, Chou, CH, Hu, HT, Lu, CY, Liou, JY, Chao, SY, Hour, TC and Pu, YS. 2011. UBE2M-mediated p27Kip1 degradation in gemcitabine cytotoxicity. (pdf)	Biochem. Pharmacol. 2011. 82(1):35-42. (SCI) (*corresponding author)	IF: 4.889 ranking: 20/249 (2010)
25	Liu, CH, Chen, CY, Huang, AM* and Li, JH*. Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1. (pdf)	J Ethnopharmacology 2011 137(1): 503-511 (SCI) (*co-correspondence)	IF:2.466 ranking: 37/187 (2010)
26	Lin, KW, Huang, AM, Hour, TC, Yang, SC*, Pu, YS and Lin, CN*. 2011. 18£]-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. (pdf)	Bioorg Med Chem 2011. 19(14):4274-85	IF:2.978 ranking: 15/54 (2010)
27	Wu, SR, Li, CF, Hung, LY, Huang, AM, Tseng, JT, Tsou, JH and Wang, JM.* 2011. CCAAT/enhancer binding protein delta mediates TNFalpha-induced aurora kinase C transcription and promotes genomic instability. (pdf)	J. Biol. Chem. 2011. 286(33):28662-70	IF: 5.328 ranking: 50/286 (2010)
28	Tu, HY#, Huang, AM#, Teng, CH#, Hour, TC, Yang, SC*, Pu, YS and Lin, CN*. 2011. Anthraquinone derivatives induce G2/M cell cycle arrest and apoptosis in NTUB1 cells. (pdf)	Bioorg Med Chem. 2011. 19: 5670-5678 (#Co-first author)	IF:2.978 ranking: 15/54 (2010)
29	Lin, KW, Huang, AM, Yang, SC*, Weng, JR, Hour, TC, Pu, YS, and Lin, CN*. Cytotoxic and antioxidant constituents from Garcinia subelliptica. (pdf)	Food Chemistry. 2012. 135 (2): 851-859	IF 3.655 ranking: 3/71 (2011)
30	Lin, KW, Lin, ZY, Huang, AM, Weng, JR, Yen, MH, Yang, SC*, Lin, CN*. Lantabetulic Acid Derivatives Induce G1 Arrest and Apoptosis in Human Prostate Cancer Cells. (pdf)	Archiv der Pharmazie. 2014. 347(1): 42-53	IF: 1.54, ranking: 69/152 (2012)
31	Kao, YT, Hsu, WC, Hu, HT, Hsu, SH, Lin, CS, Chiu, CC, Lu, CY, Hour, TC, Pu, YS and Huang, AM*. Involvement of p38 MAPK in acquired gemcitabine-resistant human urothelial carcinoma sublines. (pdf)	KAOHSIUNG J MED SCI. 2014. 30(7):323-330.	IF 0.502, ranking: 104/121 (2012)
32	Hour, TC, Chung, SD, Kang, WY, Lin, YC, Chuang, SJ, Huang, AM, Wu, WJ, Huang, SP, Huang, CY, and Pu YS*. EGFR mediates docetaxel-resistance in human castration-resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1). (pdf)	Arch Toxicol. 2015. 89(4):591-605.	IF 5.215, ranking: 6/85 (2012)
33	Lin, KW, Huang, AM*, Lin, CC, Chang, CC, Hsu, WC, Hour, TC, Pu, YS , and Lin, CN*. Anti-cancer effects of ursane triterpenoid as a single agent and in combination with cisplatin in bladder cancer. (pdf)	EUROPEAN JOURNAL OF PHARMACOLOGY. 2014. 740:742-51 (*co-correspondence)	IF 2.592, ranking: 105/261 (2012)
34	Wu CM, Lin KW, Teng CH, Huang AM, Chen YC, Yen MH, Wu WB, Pu YS, Lin CN*. 2014. Chalcone derivatives inhibit human platelet aggregation and inhibit growth in human bladder cancer cells. (pdf)	Biol Pharm Bull. 2014. 37(7):1191-8.	IF 1.849, ranking: 163/261 (2012)
35	Yeh HC, Huang CN, Li CC, Chang LL, Lin HH, Ke HL, Huang AM, Liang PI, Li CF*, Wu WJ*. Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer. (pdf)	World J Urol. 2016. 34(6):835-46.	IF 2.666, ranking: 23/78 (2013)
36	Lin KW, Maitraie D, Huang AM, Wang JP, Lin CN*. Triterpenoids and an alkamide from Ganoderma tsugae. (pdf)	Fitoterapia. 2016. 108:73-80.	IF 2.345, ranking: 130/255 (2013)
37	Lin, SR, Yeh, HC, Wang, WJ, Ke, HL, Lin, HH, Hsu, WC, Chao, SY, Hour, TC, Wu, WJ, Pu, YS and Huang, AM*. MiR-193b Mediates CEBPD-induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. (pdf)	J Cell Biochem. 2017. 118(6):1563-1573.	IF 3.446, ranking 101/289 (2015)
38	Huang, AM, Lin, KW, Lin, WH, Wu, LH, Chang, HC, Ni, C, Wang, DL, Hsu, HY, Su, CL, Shih, C. 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate induced autophagic cell death in human PC3 cells. (pdf)	Chem Biol Interac. 2018. 281:60-68.	IF 3.296 (2018)
39	Hsu, WC, Lee, YC, Liang, PI, Chang, LL, Huang, AM, Lin, HH, Wu, WJ, Li, CC, Li, WM, Jhan, JH, and Ke, HL. CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. (link)	Disease Markers. 2019. 2019: 2724948.	IF 2.761 (2019)
40	Hsu, WC, Li, WM, Lee, YC, Huang, AM, Chang, LL, Lin, HH, Wu, WJ, Li, CC, Liang, PI, Ke, HL. MicroRNA-145 Suppresses Cell Migration and Invasion in Upper Tract Urothelial Carcinoma by Targeting ARF6. (link)	FASEB J. 2020. 34(4):5975-5992.	IF 5.3911 (2019)
41	Lim, LM, Kung, LF, Kuo, MC, Huang, AM, and Kuo, HT*. Timing of mTORI usage and outcomes in kidney transplant recipients. (link)	Int J Med Sci 2021. 18(5):1179-1184	IF 2.523 (2019)
42	Wu, YU, Lee, YC, L, WM, Hsu, WC, Lin, HH, Chang, LL, Huang, AM, Jhan, JH, Wu, WJ, Li, CC, Lee, HY, Yeh, HC and Ke, HL*.High Transaldolase 1 expression predicts poor survival of patients with upper tract urothelial carcinoma. (link)	Pathol Int. 2021. 71(7):463-470.	IF 2.534 (2020)
43	Chien, TM, Lee, HY, Singla, N, Margulis, V, Lotan, Y, Woldu, SL, Huang, CN, Li, CC, Ke, HL, Li, WM, Li, CY, Huang, AM, Yang, SF, Tu, HP, Wu, WJ, and Yeh, HC.*.Prognostic Factors for Contralateral Recurrence of Upper Tract Urothelial Carcinoma after Nephroureterectomy: A Large Multiregional Study. (link)	Cancers. 2021. 13(23):5935.	IF 6.639 (2021)
44	Jhan, JH, Hsu, WC, Lee, YC, Li, WM, Huang, AM, Lin, HH, Wang, CS, Wu, YR, Li, CC, Wu, WJ and Ke, HL*. MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1.(link)	Cancers. 2022. 14 (4): 880	IF 6.639 (2021)
45	Ke, HL, Lee, YC, Li, WM, Wang, CS, Hsu, WC, Lin, HH, Lee, YA, Jhan, JH, Li, CC, Yeh, HC, Wu, WJ and Huang, AM*. High Ubiquitin-Specific Protease 2a Expression Level Predicts Poor Prognosis in Upper Tract Urothelial Carcinoma.(link)	Applied Immunohistochemistry & Molecular Morphology. 2022. 30(4):304-310	IF 2.085 (2021)
46	Yuan, CH, Hsu, WC, Huang, AM, Yuan, BC, Chen, IH, Hsu, CA, Chen, RF, Chu, YM, Lin, HH and Ke, HL*. MicroRNA-145-5p modulates Kruppel-like factor 5 and inhibits cell proliferation, migration, and invasion in nasopharyngeal carcinoma. (link)	BMC Molecular and Cell Biology. 2022. 23(1):28.	IF 2.813 (2022)
47	Lim, LM, Chung, WY, Hwang , DY, Yu , CC, Ke, HL, Liang, PI, Lin, TW, Cheng, SM, Huang, AM*, and Kuo, HT*. Whole-Exome Sequencing Identified Mutational Profiles of Urothelial Carcinoma post Kidney Transplantation. (link)	Journal of Translational Medicine. 2022. 20(1):324.	IF 8.459 (2022)
48	Jhan, JH, Ke, HL, Lian, PI, Hsu, WC, Lee, YC, Lin, HH, Wu, YR, Huang, AM, Lee, HY, Yeh , HC, Wu, WJ, Li, CC, Li, WM*. High MRE11 Expression Level Predicts Poor Survival in Upper Tract Urothelial Carcinomas. (link)	Applied Immunohistochemistry & Molecular Morphology. 2023. 31(2):94-100.	IF 1.992 (2022)
49	Wang, CS, Lee, YC, Jhan, JH, Li, WM, Chang, LL, Huang, AM, Lin, HH, Wu, YR, Hsu, WC, Ke, HL*. MicroRNA-299-3p inhibits cell proliferation, motility, invasion and angiogenesis via VEGFA in upper tract urothelial carcinoma. (link)	J. Gene Med . 2023 Dec 4:e3616.	IF 4.152 (2023)
50	Lim, LM, Lee, YC, Lin, TW, Hong, ZX, Hsu, WC, Ke, HL, Hwang, DY, Chung, WY, Li, WM, Lin, HH, Kuo, HT, Huang, AM*.NTRK3 exhibits a pro-oncogenic function in upper tract urothelial carcinomas. (link)	Kaohsiung J Med Sci . 2024. 40(5):445-455.	IF 3.3 (2023)