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A-Mei Huang

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Kaohsiung Medical University

 

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Lab Introduction

Main Focus
My laboratory is mainly focusing on studying the molecular roles of transcription factor CCAAT/enhancer binding protein delta (C/EBPdelta).


Research Projects
The main projects are
1) Molecular characterization of C/EBPdelta in maintaining genomic stability in mouse embryonic fibroblasts (MEFs);
2) The role of C/EBPdelta in apoptosis and cell cycle regulation;
3) Molecular mechanisms of C/EBPdelta-mediated drug resistance in human urothelial carcinoma cells.
4) Exploration of alternative therapeutic strategies for chemo-drug resistance by identification of novel compounds with diverse biological activities.


Grants
1. The role of C/EBPdelta in the maintenance of genomic integrity (2006/1~2006/7)
Grant ID:KMU-Q095018 (MKU)
Role:Principle investigator
2. Molecular mechanisms of C/EBPdelta in apoptosis of breast tumor cells (2006/8~2007/7)
Grant ID:NSC 95-2320-B-037-048 (NSC)
Role:Principle investigator
3. The role of C/EBPdelta in cisplatin resistance (2006/12~2007/7)
Grant ID:KMU-Q096009 (KMU)
Role:Principle investigator
4. Molecular mechanisms of transcription factor Cebpd in maintenance of genome integrity in mouse embryonic fibroblasts (2008/4/1~2008/12/31)
Grant ID:KMU-M097004 (KMU)
Role:Principle investigator
5. Identification of differential expression regulatory networks associated with drug response in chemosensitive and chemoresistant breast cancer(2009/8/1~2010/7/31)
Grant ID:NSC 98-2218-E-231-002- (NSC)
Role:Co-Principle investigator
6. Molecular mechanisms of CEBPD-mediated cisplatin resistance in human urothelial carcinoma cells (2008/8~2011/7)
Grant ID:NSC 97-2320-B-037-018-MY3 (NSC)
Role:Principle investigator
7. Evaluating CEBPD-mediated pathways in human urothelial carcinoma treatment: the molecular mechanisms in drug resistance (2011/8~2012/7)
Grant ID:NSC 100-2320-B-037-013- (NSC)
Role:Principle investigator
8. Identification of dysregulated pathways using stretched metastasis-induced graph – A case study of prostate cancer (2012/8/1~2013/7/31)
Grant ID:NSC 101-2221-E-231-030- (NSC)
Role:Co-Principle investigator
9.CEBPD in the tumorigenesis of human urothelial carcinoma (2012/12/1~2013/12/31)
Grant ID:KMU-M102008 (KMU)
Role:Principle investigator
10 . PTEN in CEBPD-mediated cisplatin responsiveness and its applications (2013/8/1~2014/7/31)
Grant ID:NSC 102-2320-B-037-026- (NSC)
Role:Principle investigator
11. CEBPD-mediated chemotherapeutic drug responsiveness and resistance in urothelial carcinoma: focusing on cisplatin-AKT-CEBPD-PTEN axis (2014/8~2015/7)
Grant ID:103-2320-B-037 -029 - (Ministry of Science and Technology)
Role:Principle investigator

12. Applications of cyclooxygenase inhibitors in urothelial carcinoma and cisplatin resistant sublines and the mechanistic studies (2016/1/1~2016/12/31)
Grant ID:KMU-M105002 (KMU)
Role:Principle investigator
13. Long - term surveillance and investigation of Aedes mosquitoes in Kaohsiung City - Southern Kaohsiung Districts (2017/5/1~2017/12/31)
Grant ID: NHRI-106A1-MRCO-1017174
Role:Principle investigator
14.Refining and continuing long-term surveillance and investigation of Aedes mosquitoes in Southern Kaohsiung Districts (2018/1/1~2018/12/31)
Grant ID: NHRI-07A1-MRPP33-035
Role:Principle investigator

15. CEBPD and its miRNA targets in urothelial carcinoma progression and drug resistance development (2018/8/1~2019/07/31)
Grant ID:MOST 107-2314-B-037-014 - (Ministry of Science and Technology)
Role:Principle investigator
16. Establish and optimize the molecular analyzing method for detecting the dengue virus in Aedes mosquitoes (2019/1/1~2019/12/31)
Grant ID: NHRI-MR-108-CO-10
Role:Principle investigator

17.Molecular mechanism of CEBPD regulating microRNA miR-17-92 cluster in upper tract /urothelial carcinoma progression and drug resistance development (2019/08/1~2022/07/31)
Grant ID:MOST 108-2314-B-037-031-MY3 (Ministry of Science and Technology)
Role:Principle investigator


Posters (click)

Patents
1.專利名稱: 熊果酸衍生物及其醫護組合物
發明人: 林忠男、涂皇堯、黃阿梅、魏百祿、顏金鳳、侯自銓、楊世群、蒲永孝、翁舷誌
證書號碼: I386415 (中華民國)
2.專利名稱: 作用於微小管抗癌藥物2',5'-dimethoxychalcone衍生物之合成與活性評估
發明人: 林忠男、涂皇堯、黃阿梅、侯自銓、楊世群、蒲永孝、張建國
專利證書號碼: I419687 (中華民國)
3.專利名稱: 抗人類泌尿上皮癌之香桂超臨界萃取物、製備方法及用途
發明人: 李志琚B黃阿梅、陳中一、連培榮、劉瓊惠
專利證書號碼: I448295 (中華民國)
4.專利名稱:The anti-human urothelial carcinoma of supercritical carbon dioxide extract of cinnamomum subavenium, and the preparation process and uses
發明人: 李志琚B黃阿梅、陳中一、連培榮、劉瓊惠
(Jih-Heng Li, A-Mei Huang, Chung-Yi Chen, Pei-Jung Lien, Chiung-Hui Liu)
專利證書號碼:US8,669,377B2 (美國)
5. 專利名稱: 熊果酸衍生物及其醫護組合物
發明人: 林忠男、涂皇堯、黃阿梅、魏百祿、顏金鳳、侯自銓、楊世群、蒲永孝、翁舷誌
證書號碼: US 8729055B2 (美國)
6.專利名稱: 18β-甘草次酸衍生物及其用途
發明人: 林忠男、林凱偉、黃阿梅、侯自銓、楊世群、蒲永孝、張建國
證書號碼: I424839 (中華民國)
7.專利名稱: Derivative of 18β-glycyrrhetinic acid APT to suppress cancer cells
發明人: 林忠男、林凱偉、黃阿梅、侯自銓、楊世群、蒲永孝、張建國
證書號碼: US 8,686,178 B2 (美國)


Publications

No.
Title Journal IF and ranking
1
Huang, AM, Chang, TJ, Cho, WL, and Chou, CK. 1998. From mosquito to man: identification of a novel protein kinase, HsHPK, which is highly expressed in human hepatoma tissues.(pdf) J. Biomed. Sci. 1998. 5(2): 135-140. (SCI)

IF: 2.013
ranking: 45/82 (2008)

2
Lee, HS, Huang, AM, Huang, GT, Yang, PM, Chen, PJ, Sheu, JC, Lai, MY, Lee, SC, Chou, CK, and Chen, DS. 1998. Hepatocyte growth factor stimulates the growth and activates mitogen-activated protein kinase in human hepatoma cells. (pdf) J. Biomed. Sci. 1998. 5(3): 180-184. (SCI) IF: 2.013
ranking: 45/82 (2008)
3
Shen, HH, Huang, AM, Hoheisel, J, and Tsai, SF. 2001. Identification and characterization of a SET/NAP protein encoded by a brain-specific gene, MB20. (pdf) Genomics. 2001. 71(1): 21-33. (SCI) IF: 3.327
ranking: 37/152 (2009)
4
Liu, MA, Huang, AM, Chou, CK, Liaw, GJ, and Wu, CW. 2001. Utilization of Drosophila eye to probe the functions of two mammalian Serine/Threonine kinases, Snk and HsHPK. (pdf) J. Biomed. Sci. 2001. 8(3): 270-277. (SCI) IF: 2.013
ranking: 45/82 (2008)
5
Huang, AM, Montagna, C, Ni, Y, Sharan, S, Ried, T and Sterneck, E. 2004. Loss of CCAAT/enhancer binding protein delta promotes chromosomal instability. (pdf) Oncogene. 2004. 23(8): 1549-1557. (SCI) IF:7.216
ranking: 13/141
6
Thangaraju M, Rudelius, M, Bierie, B, Raffeld, M, Sharan, S, Hennighausen, L, Huang, AM, and Sterneck, E. 2005. C/EBP delta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution. (pdf) Development. 2005. 132(21):4675-4685. (SCI) IF: 6.812
ranking: 5/37
7
Huang, AM, Rudelius, M, Sharan, S, McAllister, JM, Raffeld, M, Christenson, LK, and Sterneck, E. 2007. The Cebpd (C/EBPdelta) gene is induced by luteinizing hormones in ovarian theca and interstitial cells but is not essential for mouse ovary function. (pdf) PLoS ONE 2007. 2: e1334. (SCI) IF: 4.351
ranking: 9/73 (2009)
8
Lin, KW#, Huang, AM#, Tu, HY, Weng, JR, Hour, TC, Wei, BL, Yang, SC, Wang, JP, Pu, YS, and Lin, CN*. 2009. Phloroglucinols inhibit chemical mediators and xanthine oxidase, and protect cisplatin-induced cell death by reducing reactive oxygen species in normal human urothelial and bladder cancer cells. (pdf)

J Agric Food Chem 2009. 57: 8782-8787. (SCI)
(#co-first author)

IF: 2.562
ranking: 2/35 (2008)
9
Tu, HY#, Huang, AM#, Wei, BL, Gan, KH, Hour, TC, Yang, SC, Pu, YS, and Lin, CN*. 2009. Ursolic acid derivatives induce cell cycle arrest and apoptosis in NTUB1 cells associated with reactive oxygen species. (pdf) Bioorg Med Chem 2009. 17: 7265-7274. (SCI)
(#Co-first author)
IF: 3.075
ranking: 10/40 (2008)
10
Pu, YS, Huang, CY, Kuo, YZ, Kang, WY, Liu, GY, Huang, AM, Yu, HJ, Lai, MK, Huang, SP, Wu, WJ, Chiou, SJ, and Hour, TC*. 2009. Characterization of membranous and cytoplasmic EGFR expression in human normal renal cortex and renal cell carcinoma. (pdf) J. Biomed. Sci. 2009. 16(1): 82-92. (SCI) IF: 2.013
ranking: 45/82 (2008)
11
Wang, YC, Tsai, YS, Huang, JL, Lee, KW, Kuo, CC, Wang, CS, Huang, AM, Chang, JG, Jong, YJ and Lin, CS*. 2010. Arecoline arrests cells at prometaphase by deregulating mitotic spindle assembly and activating spindle assembly checkpoint. (pdf) Oral Oncology. 2010. 46(4):255-62. (SCI) IF: 2.928
ranking: 5/55 (2009)
12
Chen, HL, Lin, KW, Huang, AM, Tu, HY, Wei, BL, Hour, TC, Yen, MH, Pu, Y and Lin, CN*. 2010. Terpenoids induce cell cycle arrest and apoptosis from the stems of Celastrus kusanoi associated with reactive oxygen species. (pdf)  J Agric Food Chem 2010. 58(6):3808-12. (SCI) IF: 2.469
ranking: 2/44 (2009)
13
Tu HY, Huang AM, Hour TC, Yang SC, Pu YS, and Lin CN*. 2010. Synthesis and biological evaluation of 2',5'-dimethoxychalcone derivatives as microtubule-targeted anticancer agents. (pdf) Bioorg Med Chem. 2010. 18 (6): 2089-2098. (SCI) IF: 2.822
ranking: 17/57 (2009)
14
Hour, TC, Lai, YL, Kuan, CI, Chou, CK, Wang, JM, Tu, HY, Hu, HT, Lin, CS, Wu, WJ, Pu, YS, Sterneck, E, and Huang, AM*. 2010. Transcriptional up-regulation of SOD1 by CEBPD: a potential target for cisplatin resistant human urothelial carcinoma cells. (pdf) Biochem. Pharmacol. 2010. 80(3):325-334. (SCI) (*corresponding author) IF: 4.254
ranking: 34/237 (2009)
15
Pawar, SA, Sarkar, TR, Balamurugan, K, Sharan, S, Wang, J, Zhang, Y, Dowdy, SY, Huang, AM, and Sterneck E*. 2010. C/EBPdelta targets cyclin D1 for proteasome-mediated degradation via induction of CDC27/APC3 expression. (pdf) Proc Natl Acad Sci USA. 2010. 107(20):9210-5. (SCI) IF: 9.432
ranking: 3/50 (2009)
16
Huang, CY, Chen, JYF, Wu,JE, Pu, YS, Liu, GY, Pan, MH, Huang, YT, Huang, AM, Hwang, CC, Chung, SJ, and Hour, TC*. 2010. Ling-Zhi polysaccharides potentiates cytotoxic effects of anti-cancer drugs against drug-resistant urothelial carcinoma cell.(pdf) J Agric Food Chem. 2010. 58(15):8798-805. (SCI) IF: 2.469
ranking: 2/44 (2009)
17
Wang J, Sarkar TR, Zhou M, Sharan S, Ritt DA, Veenstra TD, Morrison DK, Huang, AM, and Sterneck E*. 2010. C/EBPdelta-mediated nuclear import of FANCD2 by IPO4 augments cellular response to DNA damage. (pdf)  Proc Natl Acad Sci USA. 2010. 107(37): 16131-6. (SCI) IF: 9.432
ranking: 3/50 (2009)
18
Lin CN#, Huang AM#, Lin KW#, Hour TC, Ko HH*, Yang SC, and Pu YS. 2010. Xanthine oxidase inhibitory terpenoids of Amentotaxus formosana protect cisplatin-induced cell death by reducing reactive oxygen species (ROS) in normal human urothelial and bladder cancer cells. (pdf) Phytochemistry 2010. 71(17-18):2140-6. (SCI)
(#Co-first author)
IF: 3.104
ranking: 24/173 (2009)
19
Pan YC, Li CF, Ko CY, Pan MH, Chen PJ, Tseng JT, Wu WC, Chang WC, Huang AM, Sterneck E, and Wang JM*. 2010. CEBPD reverses RB/E2F1-mediated gene repression and participates in HMDB-induced apoptosis of cancer cells. (pdf) Clin Cancer Res. 2010. 16(23):5770-80. (SCI) IF: 6.747
ranking: 16/166 (2009)
20
Lin, KW#, Huang, AM#, Tu, HY, Lee, LY, Wu, Hour, TC, Yang, SC, Pu, YS and Lin, CN*. 2011. Xanthine Oxidase Inhibitory Triterpenoid and Phloroglucinol from Guttiferaceous Plants Inhibit Growth and Induced Apoptosis in Human NTUB1 Cells Through a ROS-Dependent Mechanism. (pdf) J Agric Food Chem. 2011. 59(1):407-14. (SCI) (#Co-first author) IF: 2.816
ranking: 2/55 (2010)
21
Ko, CY, Chang, LH, Lee, YC, Sterneck, E, Cheng, CP, Chen, SH, Huang, AM, Tseng, JT, and Wang, JM*. 2010. CAAT/enhancer binding protein delta (CEBPD) elevating PTX3 expression inhibits macrophage-mediated phagocytosis of dying neuron cells. (pdf) Neurobiology of Aging. 2012. 33(2): 422.e11-422.e25 (SCI) IF: 6.634
ranking: 3/45 (2010)
22
Cheng,JH#, Huang, AM#, Hour, TC, Yang, SC*, Pu, YS and Lin, CN*. 2011. Antioxidant xanthone derivatives induce cell cycle arrest and apoptosis and enhance cell death induced by cisplatin in NTUB1 cells associated with ROS. (pdf) Eur J Med Chem. 2011. 46(4):1222-31. (SCI) (#Co-first author) IF:3.193
ranking: 11/54 (2010)
23
Chao, SY, Chiang, JH*, Huang, AM*, and Chang, WS. 2011. An integrative approach to identifying cancer chemoresistance-associated pathways. (pdf) BMC Med Genomics 2011. 4(1):23-37. (SCI) (*co-correspondence) IF:3.766
ranking: 47/156 (2010)
24
Huang, AM*, Kao, YT, Toh, S, Lin, PY, Chou, CH, Hu, HT, Lu, CY, Liou, JY, Chao, SY, Hour, TC and Pu, YS. 2011. UBE2M-mediated p27Kip1 degradation in gemcitabine cytotoxicity. (pdf)
Biochem. Pharmacol. 2011. 82(1):35-42. (SCI) (*corresponding author) IF: 4.889
ranking: 20/249 (2010)
25
Liu, CH, Chen, CY, Huang, AM* and Li, JH*. Subamolide A, a component isolated from Cinnamomum subavenium, induces apoptosis mediated by mitochondria-dependent, p53 and ERK1/2 pathways in human urothelial carcinoma cell line NTUB1. (pdf)

J Ethnopharmacology 2011 137(1): 503-511 (SCI) (*co-correspondence)

IF:2.466
ranking: 37/187 (2010)
26
Lin, KW, Huang, AM, Hour, TC, Yang, SC*, Pu, YS and Lin, CN*. 2011. 18β-Glycyrrhetinic acid derivatives induced mitochondrial-mediated apoptosis through reactive oxygen species-mediated p53 activation in NTUB1 cells. (pdf) Bioorg Med Chem
2011. 19(14):4274-85
IF:2.978
ranking: 15/54 (2010)
27
Wu, SR, Li, CF, Hung, LY, Huang, AM, Tseng, JT, Tsou, JH and Wang, JM.* 2011. CCAAT/enhancer binding protein delta mediates TNFalpha-induced aurora kinase C transcription and promotes genomic instability. (pdf)
J. Biol. Chem. 2011. 286(33):28662-70 IF: 5.328 ranking: 50/286 (2010)
28
Tu, HY#, Huang, AM#, Teng, CH#, Hour, TC, Yang, SC*, Pu, YS and Lin, CN*. 2011. Anthraquinone derivatives induce G2/M cell cycle arrest and apoptosis in NTUB1 cells. (pdf) Bioorg Med Chem. 2011. 19: 5670-5678 (#Co-first author) IF:2.978
ranking: 15/54 (2010)
29
Lin, KW, Huang, AM, Yang, SC*, Weng, JR, Hour, TC, Pu, YS, and Lin, CN*. Cytotoxic and antioxidant constituents from Garcinia subelliptica. (pdf) Food Chemistry. 2012.
135 (2): 851-859

IF 3.655
ranking: 3/71 (2011)

30
Lin, KW, Lin, ZY, Huang, AM, Weng, JR, Yen, MH, Yang, SC*, Lin, CN*. Lantabetulic Acid Derivatives Induce G1 Arrest and Apoptosis in Human Prostate Cancer Cells. (pdf) Archiv der Pharmazie. 2014. 347(1): 42-53  IF: 1.54, ranking: 69/152 (2012)
31
Kao, YT, Hsu, WC, Hu, HT, Hsu, SH, Lin, CS, Chiu, CC, Lu, CY, Hour, TC, Pu, YS and Huang, AM*. Involvement of p38 MAPK in acquired gemcitabine-resistant human urothelial carcinoma sublines. (pdf) KAOHSIUNG J MED SCI. 2014. 30(7):323-330. IF 0.502, ranking: 104/121 (2012)
32
Hour, TC, Chung, SD, Kang, WY, Lin, YC, Chuang, SJ, Huang, AM, Wu, WJ, Huang, SP, Huang, CY, and Pu YS*. EGFR mediates docetaxel-resistance in human castration-resistant prostate cancer through the Akt-dependent expression of ABCB1 (MDR1). (pdf) Arch Toxicol. 2015. 89(4):591-605.

IF 5.215, ranking: 6/85 (2012)

 

33
Lin, KW, Huang, AM*, Lin, CC, Chang, CC, Hsu, WC, Hour, TC, Pu, YS , and Lin, CN*. Anti-cancer effects of ursane triterpenoid as a single agent and in combination with cisplatin in bladder cancer. (pdf) EUROPEAN JOURNAL OF PHARMACOLOGY. 2014. 740:742-51 (*co-correspondence)

IF 2.592, ranking: 105/261 (2012)

 

34
Wu CM, Lin KW, Teng CH, Huang AM, Chen YC, Yen MH, Wu WB, Pu YS, Lin CN*. 2014. Chalcone derivatives inhibit human platelet aggregation and inhibit growth in human bladder cancer cells. (pdf) Biol Pharm Bull. 2014. 37(7):1191-8. IF 1.849, ranking: 163/261 (2012)
35 Yeh HC, Huang CN, Li CC, Chang LL, Lin HH, Ke HL, Huang AM, Liang PI, Li CF*, Wu WJ*. Overexpression of PTP4A3 is associated with metastasis and unfavorable prognosis in bladder cancer. (pdf) World J Urol. 2015 Oct 3 [Epub ahead of print] IF 2.666, ranking: 23/78 (2013)
36 Lin KW, Maitraie D, Huang AM, Wang JP, Lin CN*. Triterpenoids and an alkamide from Ganoderma tsugae. (pdf) Fitoterapia. 2016. 108:73-80.

IF 2.345, ranking: 130/255 (2013)

37 Lin, SR, Yeh, HC, Wang, WJ, Ke, HL, Lin, HH, Hsu, WC, Chao, SY, Hour, TC, Wu, WJ, Pu, YS and Huang, AM*. MiR-193b Mediates CEBPD-induced Cisplatin Sensitization Through Targeting ETS1 and Cyclin D1 in Human Urothelial Carcinoma Cells. (pdf) J Cell Biochem. 2017. 118(6):1563-1573. IF 3.446, ranking 101/289 (2015)
38 Huang, AM, Lin, KW, Lin, WH, Wu, LH, Chang, HC, Ni, C, Wang, DL, Hsu, HY, Su, CL, Shih, C. 1-Hydroxy-3-[(E)-4-(piperazine-diium)but-2-enyloxy]-9,10-anthraquinone ditrifluoroactate induced autophagic cell death in human PC3 cells. (pdf) Chem Biol Interac. 2018. 281:60-68. IF 3.296 (2018)
39
Hsu, WC, Lee, YC, Liang, PI, Chang, LL, Huang, AM, Lin, HH, Wu, WJ, Li, CC, Li, WM, Jhan, JH, and Ke, HL. CSF-1 Overexpression Predicts Poor Prognosis in Upper Tract Urothelial Carcinomas. (pdf) Disease Markers. Volume 2019, Article ID 2724948. IF 2.761 (2019)
       

Tel (O): 07-3121101 ext. 2138-17, Fax : 07-3223075, E-mail: amhuang@kmu.edu.tw
100, Shih-Chuan 1st Road, Kaohsiung, 80708, Taiwan
Graduate Institute of Clinical Medicine, College of Medicine, Kaohsiung Medical University
Medical Research Building, Rm416
Updated on September 30, 2019
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